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Eine neue Azepinring‐Synthese
Author(s) -
Kvita Vratislav,
Sauter Hanspeter,
Rihs Grety
Publication year - 1989
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19890720306
Subject(s) - azepine , chemistry , ring (chemistry) , derivative (finance) , decarboxylation , stereochemistry , organic chemistry , catalysis , financial economics , economics
A New Azepine‐Ring Synthesis A new one‐step synthesis of an azepine ring is described. The 2 H ‐pyran‐2‐one ring of methyl cumalate ( 8 ) or cumalaldehyde ( 2 ) upon reaction with an 1‐aminoacryl derivative, e.g. 1 or 6 , is opened with subsequent decarboxylation to give a 1‐aminobutadiene derivative that undergoes an electrocyclic ring closure to the azepine ring ( Schemes 1 and 2 ).