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Synthesis and Characterisation of the Sodium and Lithium Cryptates of Macrobicyclic Ligands incorporating pyridine, bipyridine, and biisoquinoline units
Author(s) -
Alpha Béatrice,
Anklam Elke,
Deschenaux Robert,
Lehn JeanMarie,
Pietraskiewiez Marek
Publication year - 1988
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19880710515
Subject(s) - chemistry , pyridine , lithium (medication) , sodium , combinatorial chemistry , bicyclic molecule , bipyridine , inorganic chemistry , medicinal chemistry , organic chemistry , crystal structure , endocrinology , medicine
Sythetic procedures have been deweloped for the preparation of sodium and lithium cryptates of the macrabicyclic ligands 1–11 containing pyridine, bipyridine, and biisoquinoline groups. They involve stepwise construction of the bicyclic system as will as direct macrobicyclisation procedures (Scheme 1) and give access to both symmetrical and dissymmetrical structures. Marked cation template effects have been found that facilitate the cyclisation processes. The ligands 1–11 were isolated as their cryptates with Na + or Li + cations.