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Synthesis of selectively trifluoromethylated pyridine derivaties as potential antihypertensives
Author(s) -
Lang Robert W.,
Wenk Paul F.
Publication year - 1988
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19880710312
Subject(s) - chemistry , trifluoromethyl , pyridine , potassium , combinatorial chemistry , transformation (genetics) , stereochemistry , medicinal chemistry , organic chemistry , biochemistry , alkyl , gene
A general synthesis of selectively 6‐(trifluoromethyl)‐substitued 2(1 H )‐pyridinones is described. Further transformation of one of these compounds leads to the new CF 3 ‐containing potassium‐channel openers 2a and 2b .
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