Konformationsanalysen von Modell‐Tripeptiden: Der Einfluss von α,α‐disubstituierten α‐Aminosäuren auf die Sekundärstruktur. Teil I. NMR‐ und CD‐Untersuchungen

Conformational Analysis of Tripeptide Models: The Influence of α,α‐disubstituted α‐Amino Acids on the Secondary Structure. NMR and CD Investigations The conformational properties of α,α‐disubstituted α‐amino acids are discussed on the basis of NMR, CD, X‐ray, and molecular‐mechanics studies on tripeptide models 1 . It is shown that different disubstituted amino acids do not exert the same influence on secondary‐structure formation. Thus, the choice of substituents allows the construction and stabilisation of different conformations of oligopeptide chains.