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L‐Carnitine. Novel Synthesis and Determination of the Optical Purity
Author(s) -
Voeffray Robert,
Perlberger JeanClaude,
Tenud Leander,
Gosteli Jacques
Publication year - 1987
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19870700811
Subject(s) - chemistry , enantiomer , enantiomeric excess , optical rotation , reagent , hydrochloride , resolution (logic) , specific rotation , carnitine , derivative (finance) , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , enantioselective synthesis , catalysis , biochemistry , artificial intelligence , computer science , financial economics , economics
A new route to L‐carnitine ( 1 ) based on the resolution of th trimethylammonium derivative 5 is described. The enantiomeric purity of 1 is determined by 1 H‐NMR of its O ‐acetyl hydrochloride 11 using [Eu(hfc) 3 ] as chiral shift reagent. The optical rotation of 1 with an enantiomeric purity ≥99% is [α] 25 D=−31.3° ( c = 10, H 2 O).