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Synthesis of 1‐Fluoro‐2‐amino‐1,3‐cyclohexadienes and 1‐Fluorobicyclo[2.2.2]octan‐2‐ones
Author(s) -
PickSchliebs Heike,
Margaretha Paul
Publication year - 1987
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19870700720
Subject(s) - chemistry , hydrolysis , acrylate , methyl acrylate , conjugated system , stereochemistry , organic chemistry , medicinal chemistry , polymer , monomer , copolymer
Conjugated β‐fluoro‐enamines 4 undergo cycloaddtion to methyl acrylate regio‐ and stereospecifically, affording the 1‐fluorobicyclo[2.2.2]octan‐2‐one 6a after hydrolysis.