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Stereoselective Syntheses of Tetrahydrolipstatin and of an Analogue, Potent Pancreatic‐Lipase Inhibitors Containing a β‐Lactone Moiety
Author(s) -
Barbier Pierre,
Schmeider Fernand,
Widmer Ulrich
Publication year - 1987
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19870700522
Subject(s) - chemistry , moiety , pancreatic lipase , stereoselectivity , lactone , stereochemistry , lipase , triacylglycerol lipase , organic chemistry , enzyme , catalysis
Tetrahydrolipstatin ( 1 ) and itsanalogue 2 are representatives of a new class of pancreatic‐lipase inhibtors. Two stereoselective synthetic approaches are described.
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