Nucleotides. Part XXVII  Bis[2‐( p ‐nitrophenyl)ethyl] Phosphorochloridate, a New Versatile Phosphorylating Agent in Nucleotide Chemistry | Zendy

Himmelsbach Frank | Zendy; Charubala Ramamurthy | Zendy; Pfleiderer Wolfgang | Zendy

Premium

Nucleotides. Part XXVII Bis[2‐( p ‐nitrophenyl)ethyl] Phosphorochloridate, a New Versatile Phosphorylating Agent in Nucleotide Chemistry

Author(s) -

Himmelsbach Frank,

Charubala Ramamurthy,

Pfleiderer Wolfgang

Publication year - 1987

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19870700508

Subject(s) - chemistry , synthon , nucleotide , oligonucleotide , phosphorylation , stereochemistry , combinatorial chemistry , organic chemistry , biochemistry , dna , gene

A new, versatile phosphorylating agent, bis[2‐( p ‐nitrophenyl)ethyl] phosphorochloridate ( 3 ), has been prepared and is used for 3′‐ and/or 5′‐phosphorylations of nucleosides. The resulting bis[2‐( p ‐nitrophenyl)ethyl] phosphotriesters are versatile synthons in oligonucleotide synthesis leading finally to 3′‐ and/or 5′‐terminated monophosphates in excellent yields.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research