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Synthetic Models of the Active Site of Cytochrome P‐450. 1st Communication. The Synthesis of a Doubly‐Bridged Iron(II)‐Porphyrin Carrying a Tightly Bound Thiolate Ligand
Author(s) -
Stäubli Beat,
Fretz Heinz,
Piantini Umberto,
Woggon WolfDietrich
Publication year - 1987
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19870700425
Subject(s) - chemistry , porphyrin , steric effects , cytochrome , ligand (biochemistry) , heme , stereochemistry , active site , substrate (aquarium) , derivative (finance) , tetraphenylporphyrin , photochemistry , enzyme , biochemistry , receptor , oceanography , financial economics , economics , geology
The doubly‐bridged iron(II)‐tetraphenylporphyrin derivative 6 , carrying a sterically fixed S − ligand in the ‘proximal’ position and the substrate at the ‘distal’ site, was synthesised as an enzyme model for cytochrome P‐450. Compound 36 , the CO complex of 6 , displays a split Soret band (403 and 457 nm) similar to the native cytochrome P‐450.