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3,7‐Dioxaazelaamides as Ionophores for Lithium Ion Selective Liquid Membrane Electrodes
Author(s) -
Metzger Erich,
Aeschimann Roland,
Egli Martin,
Suter Gaby,
Dohner René,
Ammann Daniel,
Dobler Max,
Simon Wilhelm
Publication year - 1986
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19860690806
Subject(s) - chemistry , ionophore , membrane , lithium (medication) , ion , electrode , ion selective electrode , inorganic chemistry , chromatography , selectivity , organic chemistry , biochemistry , medicine , endocrinology , catalysis
Lipophilic neutral carriers were synthesized which show Li + /Na + selectivities of up to ca. 80 in highly lipophilic liquid membranes. The sensor membranes exhibit improved response times and increased lifetimes as compared to systems described earlier. They allow reliable measurements of Li + in blood serum within the clinical concentration range. A 1:1 Li + /ionophore complex of one representative ( N , N , N ′, N ′‐tetracyclohexyl‐5,5‐dimethyl‐3,7‐dioxaazelaamide) has been prepared, and its structure was elucidated by X‐ray analysis.