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Die Synthese von 6,7‐Dihydro‐2 H ‐pyrimido[6, 1‐ a ]isochinolin‐4(3 H )‐onen und analogen Verbindungen und deren Wirkung als Blutpättchenaggregationshemmer
Author(s) -
Kienzle Frank,
Bounameaux Yves,
Minder Rudolf E.,
Muggli Reto
Publication year - 1986
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19860690722
Subject(s) - chemistry , stereochemistry , platelet aggregation , agonist , phosphodiesterase , platelet , enzyme , biochemistry , receptor , immunology , biology
Synthesis of 6,7‐Dihydro‐2 H ‐pyrimido[6,1‐ a ]isoquinolin‐4(3 H )‐ones and Analogous Compounds and their Activity as Blood‐Platelet Inhibitors The synthesis of 6,7‐dihydro‐2 H ‐pyrimido[6,1‐ a ]isoquinolin‐4(3 H )‐ones and of analogous compounds is described. These compounds are powerful phosphodiesterase inhibitors and, therefore, inhibit blood‐platelet aggregation independent of the agonist. They exhibit, too, cardiac activities. However, there is evidence for selective action. A structure‐activity relationship for platelet‐aggregation inhibitors is discussed.