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Thermal Methyl‐Group Transfer between Methylcobalt(III) Corrinates and Cobalt(II) Corrinates. Equilibration Experiments with Heptamethyl Cobyrinates and Cobalamins
Author(s) -
Kräutler Bernhard,
Hughes Mark,
Caderas Christian
Publication year - 1986
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19860690708
Subject(s) - chemistry , homolysis , perchlorate , aqueous solution , cobalt , nucleotide , inorganic chemistry , stereochemistry , medicinal chemistry , crystallography , ion , organic chemistry , radical , biochemistry , gene
Separate neutral aqueous solutions of either (a) methylcob(III)alamin ( 2 ) and (heptamethyl cob(II)yrinate) perchlorate ( 3 ) or of b) cob(II)alamin ( = vitamin B 12r ; ( 4 ) and [ Co β‐methyl(heptamethyl cob(III)yrinate)] perchlorate ( 5 ) equilibrated thermally at r.t. according to 2 + 3 ⇄ 4 + 5 . The corresponding equilibrium constant K e was determined ( K e = 0.63 ± 0.15). This equilibration experiment indicates that the coordination of the nucleotide function in methylcob(II)alamin ( 2 ) hardly affects the thermodynamics of the CoC bond homolysis in aqeous solution when compared to nucleotide‐free methylcorrinoids such as 5 .