Thermal Methyl‐Group Transfer between Methylcobalt(III) Corrinates and Cobalt(II) Corrinates. Equilibration Experiments with Heptamethyl Cobyrinates and Cobalamins | Zendy

Kräutler Bernhard | Zendy; Hughes Mark | Zendy; Caderas Christian | Zendy

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Thermal Methyl‐Group Transfer between Methylcobalt(III) Corrinates and Cobalt(II) Corrinates. Equilibration Experiments with Heptamethyl Cobyrinates and Cobalamins

Author(s) -

Kräutler Bernhard,

Hughes Mark,

Caderas Christian

Publication year - 1986

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19860690708

Subject(s) - chemistry , homolysis , perchlorate , aqueous solution , cobalt , nucleotide , inorganic chemistry , stereochemistry , medicinal chemistry , crystallography , ion , organic chemistry , radical , biochemistry , gene

Separate neutral aqueous solutions of either (a) methylcob(III)alamin ( 2 ) and (heptamethyl cob(II)yrinate) perchlorate ( 3 ) or of b) cob(II)alamin ( = vitamin B 12r ; ( 4 ) and [ Co β‐methyl(heptamethyl cob(III)yrinate)] perchlorate ( 5 ) equilibrated thermally at r.t. according to 2 + 3 ⇄ 4 + 5 . The corresponding equilibrium constant K e was determined ( K e = 0.63 ± 0.15). This equilibration experiment indicates that the coordination of the nucleotide function in methylcob(II)alamin ( 2 ) hardly affects the thermodynamics of the CoC bond homolysis in aqeous solution when compared to nucleotide‐free methylcorrinoids such as 5 .

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