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Stoffwechselprodukte von Mikroorganismen. 236. Mitteilung . Schwefelhaltige Ansa‐Verbindungen des Naphthomycin‐Typus
Author(s) -
Meyer Michael,
KellerSchierlein Walter,
Megahed Salva,
Zähner Hans,
Segre Annalaura
Publication year - 1986
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19860690610
Subject(s) - chemistry , moiety , stereochemistry , thioether , residue (chemistry) , streptomyces , bacteria , sulfur , strain (injury) , microorganism , organic chemistry , medicine , biology , genetics
Metabolites of Microorganisms. Sulfur‐Containing Ansa Compounds of the Naphthomycin Type From a strain of Streptomyces (Tü 2357) in addition to naphthomycin A, 4 new yellow pigments were isolated and their structures determined by spectroscopic comparison with naphthomycin A. Whereas the naphthomycins D and E are simple derivatives of naphthomycin A, having OH and H, respectively, instead of Cl, the naphthomycins F and G contain an N ‐acetylcysteine residue linked to the aromatic moiety by a thioether group. Degradations with O 3 yielded identical products from the naphthomycins A, D, F, and G, showing coincident configurations in parts of the molecules. Naphthomycin F shows some biological activity against gram‐positive bacteria and fungi, although much weaker than naphthomycin A. The naphthomycins D, E, and G are inactive against microorganisms.