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Neue Synthese von Vinblastinderivaten; 20′‐Deethyl‐20′‐deoxyvinblastin und 20′‐Deethyl‐20′‐deoxy‐C′‐homovinblastin Vorläufige Mitteilung
Author(s) -
Schill Gottfried,
Priester Claus Ulrich,
Windhövel Udo Frank,
Fritz Hans
Publication year - 1986
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19860690225
Subject(s) - chemistry , vindoline , vinblastine , stereochemistry , derivative (finance) , medicine , surgery , chemotherapy , financial economics , economics
A New Synthesis of the Vinblastine Derivatives 20′‐Deethyl‐20‐deoxyvinblastine and 20′‐Deethyl‐20′‐deoxy‐C′‐homovinblastine A new synthesis of vinblastine derivatives is described. In the key step, the chloroindolenine derivative 14 was reacted with vindoline ( 2 ) to give, after cyclization, stereospecifically 17/I and 20′‐deethyl‐20′‐deoxyvinblastine ( 17/II ). In an analogous manner, the epimeric C′‐homovinblastine derivatives 21/I‐21/IV were synthesized.