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Optical Resolution of ( RS )‐Pantolactone through Amide Formation
Author(s) -
Fizet Christian
Publication year - 1986
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19860690220
Subject(s) - chemistry , resolution (logic) , amide , amine gas treating , stereochemistry , organic chemistry , artificial intelligence , computer science
The optical resolution of ( RS )‐pantolactone ( 1 ) is carried out through formation of diastereoisomeric amides. These are separated by a single hot washing with CH 2 C1 2 or CHC1 3 . The used asymmetric amine, (1 R )‐3‐ endo ‐aminoborneol ( 4 ), is readily accessible and can be recovered almost quantitatively after resolution.
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