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Synthesis of (5 R ,8 S ,10 R )‐6‐(Allyloxy)‐ and (5 R ,8 S ,10 R )‐6‐(Propyloxy)ergolines from the 6‐Methyl Precursors
Author(s) -
Nordmann René,
Gull Peter
Publication year - 1986
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19860690129
Subject(s) - chemistry , sigmatropic reaction , stereochemistry , medicinal chemistry
Novel (5 R ,8 S ,10 R )‐6‐(allyloxy)‐ and (5 R ,8 S ,10 R )‐6‐(propyloxy)ergolines have been synthesized by use of a Meisenheimer [2,3]‐sigmatropic rearrangement of a (5 R ,8 S ,10 R )‐6‐allyl‐ergoline N 6 ‐oxide as key step.
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