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Conformation‐Odor Relationships in Norlabdane Oxides
Author(s) -
Ohloff Günther,
Vial Christian,
Demole Edouard,
Enggist Paul,
Giersch Wolfgang,
Jégou Elise,
Caruso Andrew J.,
Polonsky Judith,
Lederer Edgar
Publication year - 1986
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19860690120
Subject(s) - chemistry , odor , derivative (finance) , event (particle physics) , stereochemistry , organic chemistry , physics , quantum mechanics , financial economics , economics
Conformational factors have been found responsible for the dramatic change in odor between (−)‐deoxyambreinolide ( 12 ) and its (+)‐epi derivative 13 . The presumably molecular event during the receptor interaction has been simulated by the diastereoisomeric 11‐methyl‐ ambrox derivatives 3 and 5 as model compounds.
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