The Reductive Conversion of Some Cyclic and Acyclic  vic ‐Epoxides to Alcohols by Means of Lithium Aluminium Hydride/Aluminium Trichloride | Zendy

Andrejević Vladimir | Zendy; Bjelaković Mira | Zendy; Mihailović Milan M. | Zendy; Mihailović Mihailo Lj. | Zendy

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The Reductive Conversion of Some Cyclic and Acyclic vic ‐Epoxides to Alcohols by Means of Lithium Aluminium Hydride/Aluminium Trichloride

Author(s) -

Andrejević Vladimir,

Bjelaković Mira,

Mihailović Milan M.,

Mihailović Mihailo Lj.

Publication year - 1985

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19850680727

Subject(s) - chemistry , lithium aluminium hydride , aluminium , epoxide , molar ratio , lithium (medication) , aluminum hydride , hydride , organic chemistry , medicinal chemistry , inorganic chemistry , catalysis , hydrogen , medicine , methoxide , endocrinology

Unsubstituted medium‐ring 1,2‐epoxycycloalkanes and certain vic ‐epoxyalkanes are reduced to the corresponding alcohols very slowly when LiAlH 4 alone is used as reducing agent. However, the combination of LiAlH 4 and AlCl 3 , in a 2:1 molar ratio (with respect to 1 mol‐equiv. of epoxide) used in refluxing Et 2 O, greatly enhances these reductions, rendering them of interest for practical purposes.

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