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Nucleoside und Nucleotide . Teil 22. Synthese eines Tridecanucleosiddodecaphosphats, das die unnatürliche Base 2(1 H )‐Pyrimidinon enthält
Author(s) -
Altermatt Rolf,
Tamm Christoph
Publication year - 1985
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19850680221
Subject(s) - chemistry , pentamer , trimer , nucleotide , nucleoside , stereochemistry , histone octamer , base (topology) , biochemistry , dimer , dna , organic chemistry , mathematics , nucleosome , gene , histone , mathematical analysis
Nucleosides and Nucleotides. Part 22. Synthesis of a Tridecanucleoside Dodecaphosphate Containing the Unnatural Base 2(1 H )‐Pyrimidinone The tridecanucleosid dodecaphosphate d(TpTpMpCpGpTpCpApApApApTpC incorporating the modified nucleoside 1‐(2′‐deoxy‐β‐D‐ribofuranosyl)‐2(1 H )‐pyrimidione (M d , 2 ) was synthesized using the triester method. The intermediates were the suitably protected trimer d(TpTpM) and the pentamer d(TpTpMpCpG). The latter was condensed with the protected octamer d(TpCpApApApApTpC) to yield the desired tridecanucleotide.