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Synthesis of Macrobicyclic Polyamines by Direct Macrobicyclisation via Tripode‐Tripode Coupling
Author(s) -
Dietrich Bernard,
Hosseini Mir Wais,
Lehn JeanMarie,
Sessions Richard B.
Publication year - 1985
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19850680202
Subject(s) - chemistry , coupling (piping) , sequence (biology) , stereochemistry , biochemistry , mechanical engineering , engineering
The synthesis of five macrobicyclic polyamines 1 – 5 is described following a route in which the macrobicycle is formed by the coupling of two tripodal subunits. Such a sequence is appreciably shorter than the stepwise construction via a macrocycle, and may give higher yields, as illustrated by the case of bis‐tren 3 , which has been synthesized following both routes.