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Skeletal Migrations Observed during the Cob(I)alamin‐Catalyzed Reduction of 4β‐( tert ‐Butyl)‐1β‐(1‐methylvinyl)cyclohexanecarbaldehyde
Author(s) -
Ziegler Carl B.,
Fischli Albert
Publication year - 1985
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19850680122
Subject(s) - chemistry , catalysis , reduction (mathematics) , cobalt , medicinal chemistry , scheme (mathematics) , stereochemistry , organic chemistry , geometry , mathematics , mathematical analysis
During the cob(I)alamin( 1(I) )‐catalyzed reduction of 3 , intermediate formation of 2 and final generation of 4–10 was observed (see Scheme 1, cf. Tables 1 and 2 ). Identical products in similar ratios were generated starting from either 2 or 3 . Accepting the intermediate formation of six interconnected cobalt complexes, i.e. A–F (cf. Scheme 2) , the generation of all the products observed can be explained.