Premium
Synthese eines 2,5,7,10‐substituierten 1,6‐Methano[10]annulens, seine Methylierung, Ätherspaltung und Deprotonierung
Author(s) -
Neidlen Richard,
Hartz Georg
Publication year - 1984
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19840670821
Subject(s) - chemistry , deprotonation , annulene , methanol , reagent , toluene , methylation , sulfonic acid , medicinal chemistry , cleavage (geology) , nuclear magnetic resonance spectroscopy , salt (chemistry) , ether , stereochemistry , organic chemistry , ion , biochemistry , geotechnical engineering , fracture (geology) , engineering , gene
Synthesis of a 2,5,7,10‐Substituted 1,6‐Methanol[10]annulene, its Methylation, Ether Cleavage; and Deprotonation The synthesis of 2,7 ‐di(tert ‐butoxy)‐1,6‐methanol[10]annulene derivatives 2 and 3 are described. Methylation of 3 gave 4 , and 4 was transformed, on treatment with p ‐toluene sulfonic acid, to the salt 5 . Basic reagents deprotonated 5 ; the resulting solution was analyzed by 1 H‐NMR spectroscopy.