The Structure of Diastereomeric Oxaprotiline Metabolites. An NMR Study | Zendy

Winkler Tammo | Zendy; Dieterle Walter | Zendy; Hung Paul | Zendy; Rihs Grety | Zendy; Kriemler HansPeter | Zendy

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The Structure of Diastereomeric Oxaprotiline Metabolites. An NMR Study

Author(s) -

Winkler Tammo,

Dieterle Walter,

Hung Paul,

Rihs Grety,

Kriemler HansPeter

Publication year - 1984

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19840670809

Subject(s) - chemistry , diastereomer , stereochemistry , metabolite , biochemistry

The structure of phenolic metabolites of oxaprotiline, obtained from a study with rats and dogs, are assigned with NMR‐spectroscopic methods in combination with MS data and an X‐ray structure analysis of synthetic (9 R *,2′ S *)‐2‐chlorooxaprotiline, the metabolites are shown to be (9 R *,2′ R *)‐2‐hydroxy, 3‐hydroxy‐, and 2‐hydroxy‐3‐methoxyoxaprotiline, and (9 R *,2′ S *)‐2‐hydroxy‐, 3‐hydroxy‐, and 3‐hydroxy‐2‐methoxyoxaprotiline, as well as 2,6‐dihydroxyoxaprotiline.

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