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Milde alkalische Hydrolyse von Aconitin
Author(s) -
Katz Alfred,
Rudin Hanspeter
Publication year - 1984
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19840670740
Subject(s) - chemistry , aconitine , hydrolysis , alkaline hydrolysis , medicinal chemistry , organic chemistry , stereochemistry , chromatography
Mild Alkaline Hydrolysis of Aconitine Hydrolysis of aconitine ( 1 ) with 0.04N K 2 CO 3 in 90% MeOH at room temperature yields, besides the alkamine aconine 3 considerable amounts of 8‐ O ‐methylaconine ( 6 ) and smaller quantities of desbenzoyl‐pyroaconitine ( 4 ) and 16‐ epi ‐desbenzoyl‐pyroaconitine ( 5 ). Better yields of 4 and 5 are obtained when heating a solution of aconitine in 0.04N K 2 CO 3 in 90% EtOH.
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