Further Syntheses of Optically Active Verrucarinic Acid, 43rd Communication of Verrucarins and Roridins | Zendy

Grossen Peter | Zendy; Herold Peter | Zendy; Mohr Peter | Zendy; Tamm Christoph | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Further Syntheses of Optically Active Verrucarinic Acid, 43rd Communication of Verrucarins and Roridins

Author(s) -

Grossen Peter,

Herold Peter,

Mohr Peter,

Tamm Christoph

Publication year - 1984

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19840670631

Subject(s) - chemistry , optically active , regioselectivity , malic acid , glyoxylate cycle , alkylation , stereoselectivity , stereochemistry , organic chemistry , catalysis , enzyme , citric acid

Two new syntheses of verrucarinic acid (2 S , 3 R ‐dihydroxy‐3‐methylpentanoic acid) and its derivatives, suitably protected for the further conversion to macrocyclic trichothecenes, are described. The first one makes use of a diastereoselective alkylation of a (−)‐( S )‐malic acid ester and the regioselective reductin of one carboxyl function toa methyl group. The second approach involves a stereoselective addition of an allylsilane to a chiral glyoxylate.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research