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An Example of Head‐to‐Head Dimerization of β 4.4 ‐Helices
Author(s) -
Lorenzi Gian Paolo,
MuriValle Valentina,
Bangerter Felix
Publication year - 1984
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19840670625
Subject(s) - chemistry , head (geology) , chloroform , vapor pressure osmometry , osmometer , stereochemistry , crystallography , vapor pressure , polymer chemistry , organic chemistry , geomorphology , geology
1 H‐NMR and vapor‐pressure osmometry results are presented, which indicate the occurrence of a rapid equilibrium involving the head‐to‐head dimerization of β 44 ‐helices in chloroform solutions of HCO‐ L ‐Ile‐( D ‐AIle‐ L ‐Ile) 4 ‐OMe. This equilibrium typifies the one that, in Urry 's view, would be responsible for the formation and breaking down of the ion‐conducting channels formed by gramicidin A in lipid bilayers.