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An efficient synthesis of α,β‐unsaturated aldehydes by a four‐carbon unit extension of Grignard reagents
Author(s) -
Cloux Roland,
Schlosser Manfred
Publication year - 1984
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19840670607
Subject(s) - chemistry , reagent , aldol reaction , halide , hydrolysis , organic chemistry , dehydration , aldol condensation , grignard reagent , aldehyde , carbon fibers , grignard reaction , catalysis , medicinal chemistry , biochemistry , materials science , composite number , composite material
Copper‐catalyzed addition of organomagnesium halides to 2‐(2,2‐diethoxyethyl)oxirane ( 1 ) affords aldol acetals 2 which upon acid treatment undergo hydrolysis and dehydration to give α,β‐unsaturated aldehydes 7 with high yields.
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