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The CAMET and CASET links for the synthesis of protected oligopeptides and oligodeoxynucleotides on solid and soluble supports
Author(s) -
Schwyzer Robert,
Felder Eduard,
MerliFailli Paola
Publication year - 1984
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19840670518
Subject(s) - chemistry , oligopeptide , bifunctional , nucleotide , oligonucleotide , biopolymer , combinatorial chemistry , protecting group , amino acid , base (topology) , solid phase synthesis , peptide , stereochemistry , biochemistry , organic chemistry , dna , polymer , catalysis , mathematical analysis , alkyl , mathematics , gene
Simple bifunctional carboxy‐ and phospho‐protecting groups are described which allow the attachment of protected amino acids and nucleotides to soluble or insoluble carriers. After chemical synthesis with conventional procedures, the completed oligopeptides or oligonucleotides can be detached by base‐catalyzed β‐elimination, leaving other protecting groups intact. These protected biopolymer segments can then be purified, characterized, and used for further synthetic work by virtue of their free carboxy or phospho groups. It is also possible to deprotect peptides and nucleotides on the supports: this procedure may be used for the preparation of affinity‐chromatographic materials.