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Monohaptenic N α ‐Benzoyl‐ L ‐lysine Derivatives as Anaphylactogens: the Importance of the Unsubstituted Carboxyl Group
Author(s) -
Guenin Raymond,
Schneider Conrad H.
Publication year - 1984
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19840670411
Subject(s) - chemistry , lysine , dinitrophenyl , group (periodic table) , stereochemistry , amino acid , organic chemistry , biochemistry , antibody , immunology , biology
N α ‐ L ‐Iysine with a 2‐carboxy‐4, 6‐dinitrophenyl (Dncp) haptenic group on the ε‐amino function is a potent anaphylactogen in the guinea pig. We prepared N ε ‐Dncp‐ N α ‐benzoly‐ L ‐Iysinamide and N ε ‐Dncp‐ N α ‐benzoyl‐ L ‐lysyl‐1‐aminopropane where the carboxyl group of Iysine is blocked. Both compounds were non‐elections of anaphylaxis.