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Nucleotide, XXI . Synthese und Eigenschaften Dihydrouridin‐haltiger Oligonucleotide
Author(s) -
Flockerzi Dieter,
Silber Gunter,
Pfleiderer Wolfgang
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660832
Subject(s) - chemistry , random hexamer , pentamer , oligonucleotide , stereochemistry , histone octamer , nucleotide , phosphoramidite , crystallography , dna , biochemistry , nucleosome , histone , gene
Nucleotides, XXI. Synthesis and Properties of Dihydrouridine‐Containing Oligonucleotides Substituted 5,6‐dihydrouridine derivatives 1, 5 , and 8 have been used in condensation reactions to form a series of dinucleosidemono‐ and dinucleosidediphosphotriesters, 13 and 16–22 , respectively. Dihydrouridine‐containing fully blocked oligomers have also been obtained by stepwise chain‐elongation and block condensations including 5 trimers (25–29) and one pentamer (31) , hexamer (32) and octamer (34) each. The new compounds were characterized by UV and partly CD spectra as well as elementary analyses. NMR spectra prove the structures but are not reported in detail.