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Nucleotide, XVII . Synthese von homogenen Adenosyl‐3′,5′‐Oligomeren nach dem Phosphotriester‐Verfahren
Author(s) -
Flockerzi Dieter,
Uhlmann Eugen,
Pfleiderer Wolfgang
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660713
Subject(s) - chemistry , trimer , pentamer , nucleotide , stereochemistry , homogeneous , adenosine , oligomer , dimer , organic chemistry , biochemistry , physics , gene , thermodynamics
Nucleotides, XVII. Synthesis of Homogeneous Adenosyl‐3′,5′‐oligomers by the Phosphotriester Method The chemical synthesis of the fully protected trimer 12 , the tetramers 11 and 23 as well as the pentamer 14 was achieved in preparative scales starting from the fully blocked adenosine‐3′‐phosphotriesters 1, 2 , and N 6 ‐benzoyl‐2′,3′‐bis‐ O ‐ (tert ‐butyldimethylsilyl)adenosine (6) . All intermediates and end products have been isolated, purified and characterized by elemental analyses, UV, and CD spectra. Deprotection of the various blocking groups proceeds without difficulties to afford the free trimeric, tetrameric, and pentameric oligoadenylates 15, 16 , and 24 in high yields.