Premium
Total Synthesis of Neplanocin A
Author(s) -
Jung Michael,
Offenbächer Gustav,
Rétey János
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660702
Subject(s) - chemistry , total synthesis , hydroxymethyl , cyclopentadiene , stereochemistry , organic chemistry , catalysis
The first total synthesis of racemic neplanocin A (1) After submitting our paper we learned that Arita et al. [J. Am. Chem. Soc.105, 4049(1983)] synthesized the natural enantioner of Neplanocin A. from cyclopentadiene and acylnitroso‐3,5‐dinitrobenzoic acid is described. The synthesis is suitable for specific isotopic labelling of the hydroxymethyl group of neplanocin A.