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1 H‐NMR Spectroscopy of Gold Drugs. High‐Resolution Studies of β‐ D ‐Thioglucosetetraacetate Phosphine Complexes of Au(I)
Author(s) -
Pregosin Paul S.,
Becker Edwin D.
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660512
Subject(s) - chemistry , phosphine , chemical shift , thio , nuclear magnetic resonance spectroscopy , proton , sulfur , spectroscopy , coordination complex , stereochemistry , crystallography , proton nmr , medicinal chemistry , metal , organic chemistry , physics , quantum mechanics , catalysis
1 H‐NMR data (11.74 Tesla) for the gold(I) complexes [R 3 P‐Au‐(2,3,4, 6‐tetra‐ O ‐acetyl‐1‐thio‐β‐ D ‐glucopyranosido‐S)] (R = Et, Cyclohexyl, C 6 H 5 , p ‐CH 3 OC 6 H 4 ) with sulfur coordination to gold, are reported. The resonances associated with the sugar protons have been assigned although these have similar chemical environments. The coordination chemical shifts, Δδ, for the AuSC H proton are ≈ 0.6 ppm, and support S‐coordination to gold.