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The Crystal Structure of 1,2‐Didehydrocrotalanine Picrate: A Macrocyclic Pyrrolizidine Alkaloid Analogue
Author(s) -
StoeckliEvans Helen,
Robins David J.
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660506
Subject(s) - chemistry , picrate , pyrrolizidine , alkaloid , pyrrolizidine alkaloid , antiparallel (mathematics) , methiodide , stereochemistry , crystal structure , indolizidine , crystallography , organic chemistry , ion , physics , quantum mechanics , magnetic field
1,2‐Didehydrocrotalanine ( 2 ) is the first synthetic macrocyclic pyrrolizidine alkaloid analogue to be studied by X‐ray crystallography. The crystal structure was solved by multisolution direct methods and refined by full‐matrix least‐squares to R = 0.036 for 693 reflections. The alkaloid analogue has an 11‐membered macrocycle containing two ester groups with their carbonyl groups nearly antiparallel.