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Conformationally Controlled Odor Perception in ‘Steroid‐type’ Scent Molecules
Author(s) -
Ohloff Günther,
Giersch Wolfgang,
Thommen Walter,
Willhalm Bruno
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660503
Subject(s) - chemistry , odor , steroid , molecule , chemoreceptor , stereochemistry , organic chemistry , biochemistry , receptor , hormone
A series of compounds possessing a ‘Steroid‐type’ scent and related to 4‐(4′‐ t ‐butylcyclohexyl)‐4‐methyl‐2‐pentanones ( 1 and 2 ) has been synthesized. The odor of these compounds has been found to be dependent on their conformation; only when the molecule can assume a steroid‐like shape there is an interaction with the odor chemoreceptor.