Synthesis and Anaphylactogenicity of Monohaptenic Carbohydrate Conjugates | Zendy

Guenin Raymond | Zendy; Schneider Conrad H. | Zendy

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Synthesis and Anaphylactogenicity of Monohaptenic Carbohydrate Conjugates

Author(s) -

Guenin Raymond,

Schneider Conrad H.

Publication year - 1983

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19830660413

Subject(s) - chemistry , conjugate , moiety , dinitrophenyl , residue (chemistry) , stereochemistry , carbohydrate , guinea pig , combinatorial chemistry , biochemistry , antibody , mathematical analysis , mathematics , immunology , biology , medicine , endocrinology

Peptidic model conjugates carrying a single 2‐carboxy‐4,6‐dinitrophenyl haptenic group, and as carbohydrate moieties D ‐gluconoyl, β‐ D ‐mannopyranosyl, 2‐deoxy‐β‐ D ‐glucopyranos‐2‐yl, or lactobionoyl residues, including the pseudocarbohydrate residue 1,3,4,5‐tetrahydroxycyclohexane‐1‐carbonyl, were synthesized. Conjugates carrying the lactobionoyl of the bis(2‐deoxy‐β‐ D ‐glucopyranos‐2‐yl) moiety were anaphylactogenic in the guinea pig, passively sensitized against 2‐carboxy‐4,6‐dinitrophenyl antigen.

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