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Hydroxyphenyl‐1‐methylpyridinium‐jodide als potentielle Reaktivatoren von mit Organophosphor‐Verbindungen vergifteten Acetylcholinesterasen
Author(s) -
Riggio Gaetano,
Hopff Wolfgang Herbert,
Hofmann Alfred André,
Waser Peter Gaudenz
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660406
Subject(s) - chemistry , iodide , sarin , acetylcholinesterase , reactivity (psychology) , medicinal chemistry , stereochemistry , organic chemistry , enzyme , medicine , alternative medicine , pathology
Hydroxyphenyl‐1‐methylpyridinium‐iodide as Potential Reactivators of Acetylcholinesterase Poisoned with Organophosphorus Compounds . It was our aim to reactivate acetylcholinesterase poisoned with sarin. We synthesized 2‐( o ‐hydroxyphenyl)‐1‐methylpyridinium‐iodide ( 9 ), 2‐( p ‐hydroxyphenyl)‐1‐methylpyridinium‐iodide ( 19 ) and 4‐( o ‐hydroxyphenyl)‐1‐methylpyridinium‐iodide ( 14 ) as potential reactivators. All substances showed moderate toxicity against mice; their reactivity potency in vitro and in vivo was negligible.