Hydroxyphenyl‐1‐methylpyridinium‐jodide als potentielle Reaktivatoren von mit Organophosphor‐Verbindungen vergifteten Acetylcholinesterasen | Zendy

Riggio Gaetano | Zendy; Hopff Wolfgang Herbert | Zendy; Hofmann Alfred André | Zendy; Waser Peter Gaudenz | Zendy

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Hydroxyphenyl‐1‐methylpyridinium‐jodide als potentielle Reaktivatoren von mit Organophosphor‐Verbindungen vergifteten Acetylcholinesterasen

Author(s) -

Riggio Gaetano,

Hopff Wolfgang Herbert,

Hofmann Alfred André,

Waser Peter Gaudenz

Publication year - 1983

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19830660406

Subject(s) - chemistry , iodide , sarin , acetylcholinesterase , reactivity (psychology) , medicinal chemistry , stereochemistry , organic chemistry , enzyme , medicine , alternative medicine , pathology

Hydroxyphenyl‐1‐methylpyridinium‐iodide as Potential Reactivators of Acetylcholinesterase Poisoned with Organophosphorus Compounds . It was our aim to reactivate acetylcholinesterase poisoned with sarin. We synthesized 2‐( o ‐hydroxyphenyl)‐1‐methylpyridinium‐iodide ( 9 ), 2‐( p ‐hydroxyphenyl)‐1‐methylpyridinium‐iodide ( 19 ) and 4‐( o ‐hydroxyphenyl)‐1‐methylpyridinium‐iodide ( 14 ) as potential reactivators. All substances showed moderate toxicity against mice; their reactivity potency in vitro and in vivo was negligible.

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