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Preparation of α‐Bromo‐ and α‐Chlorocarboxylic Acids from α‐Amino Acids
Author(s) -
Olah George A.,
Shih Joseph,
Prakash G. K. Surya
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660404
Subject(s) - chemistry , halide , pyridine , amino acid , hydrogen fluoride , potassium , potassium fluoride , strong acids , fluoride , organic chemistry , medicinal chemistry , inorganic chemistry , biochemistry
Diazotization of α‐amino acids in 48:52 ( w / w ) hydrogen fluoride/pyridine along with excess of potassium halide results in the corresponding α‐halocarboxylic acids in good to excellent yields (Table 1 and 2) .