Synthese stereoisomerer Pinanthromboxane und Evaluation der Verbindungen als Plättchenaggregationsinhibitoren

Synthesis of Stereisomeric Pinanthromboxane Derivatives and Evaluation of the Compounds as Platelet Aggregation Inhibitors Starting from the two enantiomeric myrtenols ((−)‐ 1 and (+)‐ 1 ; cf. Scheme 1 ), the synthesis of twelve stereoisomeric pinanthromboxane derivatives ((+)‐ and (−)‐ 10, ‐11, ‐14, ‐15, ‐21 and ‐22 ) is described ( cf. Schemes 1–4 ). Biological data from the evaluation as platelet aggregation inhibitors ( cf. Table 6 and 7 ), thromboxane synthetase inhibitors ( cf. Table 8 ) and from the assessment as antagonists of leukotriene E 4 induced bronchoconstriction ( cf. Table 9 ) are presented.