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Synthese stereoisomerer Pinanthromboxane und Evaluation der Verbindungen als Plättchenaggregationsinhibitoren
Author(s) -
Bounameaux Yves,
Coffey John W.,
O'Donnell Margaret,
Kling Klaus,
Quinn Ronald J.,
Schönholzer Peter,
Szente André,
Tobias Lawrence D.,
Tschopp Thomas,
Welton Ann F.,
Fischli Albert
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660331
Subject(s) - chemistry , medicinal chemistry
Synthesis of Stereisomeric Pinanthromboxane Derivatives and Evaluation of the Compounds as Platelet Aggregation Inhibitors Starting from the two enantiomeric myrtenols ((−)‐ 1 and (+)‐ 1 ; cf. Scheme 1 ), the synthesis of twelve stereoisomeric pinanthromboxane derivatives ((+)‐ and (−)‐ 10, ‐11, ‐14, ‐15, ‐21 and ‐22 ) is described ( cf. Schemes 1–4 ). Biological data from the evaluation as platelet aggregation inhibitors ( cf. Table 6 and 7 ), thromboxane synthetase inhibitors ( cf. Table 8 ) and from the assessment as antagonists of leukotriene E 4 induced bronchoconstriction ( cf. Table 9 ) are presented.