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Synthesis of 2‐Oxo‐2 H ‐[1,2,4]oxadiazolo‐[2,3‐ c ]pyrimidine‐5‐carbamates
Author(s) -
Hengartner Urs,
Muller JeanClaude,
Ramuz Henri
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660229
Subject(s) - chemistry , pyrimidine , stereochemistry , medicinal chemistry
Thermal cyclization of the pyrimidine‐ N ‐oxide dicarbamate 2 gives a 95:5 mixture of the 2‐oxo‐2 H ‐[1,2,4]oxadiazolo[2,3‐ a ]‐ and [2,3‐ c ]pyrimidinecarbamates 3 and 4. An efficient procedure for the conversion of 3 to 4 , and vice versa , is described.