Premium
Deblocking of o ‐Nitrophenylsulfenyl‐Protected Peptides by Ammonium Thiocyanate and (2‐Methyl‐1‐indolyl)acetic acid
Author(s) -
Lüscher Immanuel F.,
Schneider Conrad H.
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660219
Subject(s) - chemistry , acetic acid , ammonium thiocyanate , ethyl bromoacetate , cleavage (geology) , ammonium , thiocyanate , medicinal chemistry , ammonium acetate , organic chemistry , high performance liquid chromatography , geotechnical engineering , fracture (geology) , engineering
The thiocyanate cleavage of the N a ‐ o ‐nitrophenylsulfenyl group from peptides in solution or on a solid support proceeds effectively in the presence of (2‐methyl‐1‐indolyl)acetic acid. This scavenger was prepared from 2‐methylindole and sodium bromoacetate; it can readily be removed by extraction with base after the cleavage reaction, together with (2‐methyl‐3‐(2‐nitrophenylthio)‐1‐indolyl)acetic acid.