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Nucleoside und Nucleotide. Teil 20. Synthese von Desoxyribooligonucleotiden nach der Diester‐ und Triestermethode mit 2(1 H )‐Pyrimidinon als Base
Author(s) -
Schneider HansDieter,
Tamm Christoph
Publication year - 1983
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19830660131
Subject(s) - chemistry , nucleotide , nucleoside , stereochemistry , base (topology) , biochemistry , mathematical analysis , mathematics , gene
Nucleosides and Nucleotides. Part 20, Synthesis of Desoxyribooligonucleotides According to the Diester and Triester Method with 2(1 H )‐Pyrimidinone as Base The syntheses of the dinucleosidemonophosphate 1‐(2′‐deoxy‐b̃‐ D ‐ribofuranosyl)‐2(1 H )‐pyrimidinon‐(3′‐5′)‐2′‐deoxycytidine (M d pC d ; 4 ) and the trinucleoside‐diphosphate thymidyl‐(3′‐5′)‐thymidylyl‐(3′‐5′)‐1‐(2′‐deoxy‐b̃‐ D ‐ribofuranosyl)‐2(1 H )pyrimidinon (T d pT d pM d ; 1 ) are described, Compound 1 was synthesized by different variants of the triester method, and 4 by the diester method as well as the triester method.