Alkylative amination of non‐enolizable aldehydes with alkyl (dialkyl‐amino)titanium derivatives  Preliminary Communication | Zendy

Seebach Dieter | Zendy; Schiess Martin | Zendy

Premium

Alkylative amination of non‐enolizable aldehydes with alkyl (dialkyl‐amino)titanium derivatives Preliminary Communication

Author(s) -

Seebach Dieter,

Schiess Martin

Publication year - 1982

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19820650831

Subject(s) - chemistry , alkyl , amination , group (periodic table) , titanium , carbonyl group , tris , medicinal chemistry , organic chemistry , atom (system on chip) , catalysis , biochemistry , computer science , embedded system

The readily available tris (diethylamino)methyltitanium and related compounds (see 1 in Scheme 2 ) react with non‐enolizable aldehydes to give tertiary amines 2 ; these amines result from direct replacement of the carbonyl O‐atom by an alkyl and an amino group ( Scheme 3 ). A tentative mechanism is proposed, according to which the amino group is transferred to the carbonyl C‐atom prior to the alkyl group ( Scheme 4).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research