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Die Struktur des Curare‐Alkaloides Calebassinin‐1 183. Mitteilung uber organische Naturstoffe
Author(s) -
Guggisberg Armin,
Prewo Roland,
Bieri Jost H.,
Hesse Manfred
Publication year - 1982
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19820650830
Subject(s) - chemistry , curare , alkaloid , quinoline , stereochemistry , derivative (finance) , organic chemistry , medicine , financial economics , economics , pharmacology
The Structure of the Calabash Curare Alkaloid Calebassinine‐1 The quaternary alkaloid calebassinine, isolated 1947 from Calabash Curare. has now been separated into calebassinine‐1 and ‐2. X‐ray structure determination of calebassinine‐1 led to structure 2 with relative configuration. A possible biogenetic pathway from 2,16‐dihydroakuammicine ( 3 ) as well as its pyrolytic decomposition to 3‐ethylpyridine ( 9 ), the quinoline derivative 8 , methylchloride and norcale bassinine‐1 are discussed.