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Indolalkaloide aus Kopsia dasyrachis Ridl. 185.Mitteilung über organische Naturstoffe
Author(s) -
Homberger Katharina,
Hesse Manfred
Publication year - 1982
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19820650825
Subject(s) - chemistry , indole test , stereochemistry , derivative (finance) , ring (chemistry) , organic chemistry , financial economics , economics
Indole Alkaloids of Kopsia dasyrachis Ridl. From the leaves of Kopsia dasyrachis Ridl. three new indole alkaloids, kopsidasine‐ N ‐oxide ( 1 ), kopsidasine ( 2 ) and kopsidasinine ( 3 ) have been isolated. Reduction of 1 with SO 2 afforded 2 ; treatment of 2 with m ‐chloroperbenzoic acid gave 1 . The structure elucidation of 1 and 2 , and the deternmination of their relative configurations are based mainly on the correlation of derivative 6 with the known ring skeleton of pleiocarpine ( 9 ) ( Scheme 1 ). The structure of 3 has been established via its Hofmann degradation product 13 also prepared by treatment of 2 with CH 3 I ( Scheme 3 ).