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Nucleosides and Nucleotides. Part 19. On Detritylation with Zinc Bromide in Oligonucleotide Synthesis
Author(s) -
Waldmeier Felix,
De Bernardini Silvio,
Leach Colin A.,
Tamm Christoph
Publication year - 1982
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19820650815
Subject(s) - chemistry , zinc bromide , reagent , zinc , nucleotide , bromide , oligonucleotide , combinatorial chemistry , oligonucleotide synthesis , organic chemistry , biochemistry , dna , gene
Zinc bromide has been shown by several groups of workers to be a useful reagent in the removal of trityl protecting groups from nucleotides. An attempt is made here to establish optimum conditions for the reaction, a strange observation is reported, and a novel workup via a soluble, lipophilic zinc complex is described.