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Reaktion von 3‐Dimethylamino‐2,2‐dimethyl‐2 H ‐azirin mit 6‐Methyluracil; Kristallstruktur der Reaktionsprodukte
Author(s) -
Dähler Marlise,
Prewo Roland,
Bieri Jost H.,
Heimgartner Heinz
Publication year - 1982
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19820650735
Subject(s) - chemistry , azirine , uracil , derivative (finance) , crystal structure , hydrolysis , medicinal chemistry , stereochemistry , crystallography , organic chemistry , ring (chemistry) , dna , biochemistry , financial economics , economics
Reaction of 3‐Dimethylamino‐2,2‐dimethyl‐2 H ‐azirine with 6‐Methyluracil; Crystal Structure of the Products The reaction of 3‐dimethylamino‐2,2‐dimethyl‐2 H ‐azirine ( 1 ) with 6‐methyl‐uracil ( 4 ) in 2‐propanol at 80° yields the 4 H ‐imidazoje derivative 5 as the main product. This reaction is similar to the previously reported ones with heterocyclic compounds containing the sequence NHCONHCO. In the presence of water, 5 is easily hydrolyzed to 6 . The structures of 5 and 6 have been established by X‐ray crystallography.