Premium
Synthese makrocyclischer Lactame aus Ketonen durch Ringerweiterung. Vorläufige Mitteilung
Author(s) -
Wälchli Rudolf,
Hesse Manfred
Publication year - 1982
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19820650734
Subject(s) - chemistry , reductive amination , ring (chemistry) , amide , amination , stereochemistry , medicinal chemistry , organic chemistry , catalysis
Synthesis of Macrocyclic Lactams from Ketones by Ring Enlargement Reaction 2‐Nitroalkanon 1 was converted to the N ‐substituted amide 3 by condensation with acrylaldehyde followed by reductive amination. Under the analogous reaction conditions, 2‐nitrocyclododecanon ( 4 ) led to 12‐nitro‐15‐pentadecanlactam ( 6 ).
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom