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The Synthesis of an O ‐2‐Isooxacephem
Author(s) -
Hakimelahi Gholam Hosien,
Just George,
Ugolini Antonio
Publication year - 1982
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/hlca.19820650506
Subject(s) - chemistry , amine gas treating , tertiary amine , chloride , medicinal chemistry , organic chemistry , combinatorial chemistry
The synthesis of an iso‐oxacephem is described. Reaction of methanesulfonyl chloride with hydroxyaldylmalonates can form sulfones or sulfonates, their ratio varying with the basicity of the tertiary amine used in the sulfonation.