Alkaloid Production in  Catharanthus Roseus  Cell Cultures. XI . Biotransformation of 3′, 4′‐Anhydrovinblastine to Other Bisindole Alkaloids | Zendy

Kutney James P. | Zendy; Aweryn Barbara | Zendy; Choi Lewis S. L. | Zendy; Kolodziejczyk Pawel | Zendy; Kurz Wolfgang G. W. | Zendy; Chatson Kenneth B. | Zendy; Constabel Friedrich | Zendy

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Alkaloid Production in Catharanthus Roseus Cell Cultures. XI . Biotransformation of 3′, 4′‐Anhydrovinblastine to Other Bisindole Alkaloids

Author(s) -

Kutney James P.,

Aweryn Barbara,

Choi Lewis S. L.,

Kolodziejczyk Pawel,

Kurz Wolfgang G. W.,

Chatson Kenneth B.,

Constabel Friedrich

Publication year - 1982

Publication title -

helvetica chimica acta

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.74

H-Index - 82

eISSN - 1522-2675

pISSN - 0018-019X

DOI - 10.1002/hlca.19820650417

Subject(s) - catharanthus roseus , biotransformation , chemistry , alkaloid , apocynaceae , suspension culture , stereochemistry , cell culture , yield (engineering) , organic chemistry , botany , biochemistry , enzyme , biology , genetics , materials science , metallurgy

Biotransformation studies of 3′,4′‐anhydrovinblastine (1) in Calharanthus roseus cell suspension cultures are reported. A detailed study of one cell line, coded at „916”, has revealed that 1 is transformed to the natural bisindole alkaloids leurosine ( 2 ) and Catharine ( 3 ) in approximately 25–30 and 9–16% yield, respectively. In 24–48 h, about 40% of 1 is utilized by the cells. Conditions for biotransformation of 1 have not been optimized so the above yields quoted are not final.

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